abstract：BACKGROUND:To distinguish left ventricular outflow tract (LVOT) from right ventricular outflow tract (RVOT) origin in idiopathic outflow tract premature ventricular contractions (IOT-PVCs) patients with precordial R/S transition at lead V3 is still a challenge. We sought to develop a new electrocardiography (ECG) metho...

journal_title：International journal of cardiology

authors： Qin F,Zhao Y,Bai F,Ma Y,Sun C,Liu N,Li B,Li Y,Liu C,Liu Q,Zhou S

更新日期：2018-10-15 00:00:00

abstract：BACKGROUND:Left Anterior Fascicular Block (LAFB) occurs frequently among the elderly, and have a correlation with coronary artery disease (CAD), yet controversies regarding its clinical significance still remain. METHODS:We carried on a retrospective study involving 92 LAFB and 478 non-LAFB patients, in which anatomic...

journal_title：International journal of cardiology

authors： Ding S,Chai K,Li Y,Fang F,Yang J,Wang H

更新日期：2018-10-15 00:00:00

abstract：BACKGROUND:The comparative effectiveness and safety of individual direct oral anticoagulants (DOACs) in clinical practice is largely unknown. The study objectives were to compare effectiveness and safety of DOACs in patients with non-valvular atrial fibrillation (NVAF). METHODS:Based on nationwide registers we establi...

journal_title：International journal of cardiology

authors： Andersson NW,Svanström H,Lund M,Pasternak B,Melbye M

更新日期：2018-10-01 00:00:00

abstract：:Percutaneous coronary interventions (PCI), including balloon angioplasty and implantation of both bare metal and drug eluting coronary stents, are associated with risk of restenosis and in-stent thrombosis. A better understanding of signals that regulate cellular proliferation, neointimal formation and vessel wall thi...

journal_title：International journal of cardiology

authors： Gallo G,Pierelli G,Forte M,Coluccia R,Volpe M,Rubattu S

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Plasma trimethylamine-N-oxide (TMAO) is associated with cardiovascular disease; however specific relationships with cardiac arrhythmias are unknown. We evaluated the association between plasma TMAO and incident atrial fibrillation (AF). METHODS:Risk associations were explored among 3797 patients with suspec...

journal_title：International journal of cardiology

authors： Svingen GFT,Zuo H,Ueland PM,Seifert R,Løland KH,Pedersen ER,Schuster PM,Karlsson T,Tell GS,Schartum-Hansen H,Olset H,Svenningsson M,Strand E,Nilsen DW,Nordrehaug JE,Dhar I,Nygård O

更新日期：2018-09-15 00:00:00

abstract：BACKGROUND:Tricyclic antidepressants (TCAs) are still used in 30% of anxiety/depression cases and have been related to increased cardiovascular risk. Newer serotonin/norepinephrine reuptake inhibitors (SSRIs/SNRIs) safety remains conflicting. Our aim was to assess the risk of a first acute coronary syndrome (ACS) in pa...

journal_title：International journal of cardiology

authors： Almog R,Carasso S,Lavi I,Amir O

更新日期：2018-09-15 00:00:00

abstract：BACKGROUND:Atrial septal defects (ASDs) can be symptomatic in small children in cases of co-morbidities. Transcatheter closure remains controversial for large defects in small children. OBJECTIVE:To describe transcatheter closure of ASDs in children with device/weight ratio ≥1.5. METHODS:We retrospectively studied be...

journal_title：International journal of cardiology

authors： Houeijeh A,Hascoët S,Bouvaist H,Hadeed K,Petit J,Godart F,Fraisse A

更新日期：2018-09-15 00:00:00

abstract：BACKGROUND:For patients in whom statins are not tolerated or effective as monotherapy, proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) represent a new class of lipid lowering therapies that may reduce low-density lipoprotein cholesterol (LDL-C) levels by up to 50% and lower cardiovascular events. Whil...

journal_title：International journal of cardiology

authors： Kumar R,Tonkin A,Liew D,Zomer E

更新日期：2018-09-15 00:00:00

abstract：BACKGROUND:In a randomized trial, baroreflex activation therapy (BAT) improved exercise capacity, quality of life and NT-proBNP in patients with heart failure with reduced ejection fraction (HFrEF). In view of different mechanisms underlying HFrEF, we performed a post-hoc subgroup analysis of efficacy and safety of BAT...

journal_title：International journal of cardiology

authors： Halbach M,Abraham WT,Butter C,Ducharme A,Klug D,Little WC,Reuter H,Schafer JE,Senni M,Swarup V,Wachter R,Weaver FA,Wilks SJ,Zile MR,Müller-Ehmsen J

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Myocardial infarction (MI) is one of the most common causes of cardiac morbidity and mortality. Many evidences suggest that hypothermia have a more pronounced impact as an adjunctive therapy for MI to reduce infarct size. However, the function of long non-coding RNAs (lncRNA) in therapeutic hypothermia for M...

journal_title：International journal of cardiology

authors： Zhang J,Yu L,Xu Y,Liu Y,Li Z,Xue X,Wan S,Wang H

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:A correct measurement of the QT interval in the out-of-hospital setting is important whenever the long QT syndrome (LQTS) is suspected or a therapy might lead to drug-induced LQTS (diLQTS) because QT interval monitoring in the initial days of therapy could alert to dangerous QT prolongation. We explored whet...

journal_title：International journal of cardiology

authors： Castelletti S,Dagradi F,Goulene K,Danza AI,Baldi E,Stramba-Badiale M,Schwartz PJ

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Aortic stenosis (AS) is an active disease, but the determinants of AS progression remain largely unknown. Low levels of Fetuin-A, a powerful inhibitor of ectopic calcification, have been linked to ectopic calcium tissue deposition but its role in AS progression has not been clearly evaluated. METHODS:In our...

journal_title：International journal of cardiology

authors： Kubota N,Testuz A,Boutten A,Robert T,Codogno I,Duval X,Tubiana S,Hekimian G,Arangalage D,Cimadevilla C,Kerneis C,Vahanian A,Messika-Zeitoun D

更新日期：2018-08-15 00:00:00

abstract：BACKGROUND:Several studies have reported that hepatitis B virus (HBV) infection affects the risk of coronary heart disease. However, its association is controversial. Thus, we conducted a systematic review and meta-analysis to better understand it. METHODS:Relevant studies published before October 2017 were identified...

journal_title：International journal of cardiology

authors： Wang Y,Xiong J,Niu M,Xu W,Xu K,Zhong H

更新日期：2018-08-15 00:00:00

abstract：BACKGROUND:Data evaluating mTOR inhibitor use heart transplant (HT) patients comes from relatively small studies and controversy exists regarding their specific role. We performed a meta-analysis of randomized trials to evaluate the efficacy and safety of mTOR inhibitors in HT patients. METHODS:We performed a systemat...

journal_title：International journal of cardiology

authors： Jennings DL,Lange N,Shullo M,Latif F,Restaino S,Topkara VK,Takeda K,Takayama H,Naka Y,Farr M,Colombo P,Baker WL

更新日期：2018-08-15 00:00:00

abstract：BACKGROUND:Measurement of flow-mediated vasodilation (FMD) is an established method for assessing endothelial function. Measurement of FMD is useful for showing the relationship between atherosclerosis and endothelial function, mechanisms of endothelial dysfunction, and clinical implications including effects of interv...

journal_title：International journal of cardiology

authors： Matsui S,Kajikawa M,Maruhashi T,Hashimoto H,Kihara Y,Chayama K,Goto C,Aibara Y,Yusoff FM,Kishimoto S,Nakashima A,Noma K,Kawaguchi T,Matsumoto T,Higashi Y

更新日期：2018-08-15 00:00:00

abstract：BACKGROUND:Functional tricuspid regurgitation (FTR) commonly arises secondary to conditions affecting the left heart and is associated with right ventricular dysfunction and tricuspid annular dilatation. We set out to establish an animal model of acute RV failure (RVF) with FTR resembling the clinical features. METHOD...

journal_title：International journal of cardiology

authors： Malinowski M,Proudfoot AG,Eberhart L,Schubert H,Wodarek J,Langholz D,Rausch MK,Timek TA

更新日期：2018-08-01 00:00:00

abstract：:Doppler echocardiography is extensively used in clinical practice for the screening and detection of pulmonary hypertension (PH). It allows for accurate estimates of pulmonary artery pressures, but with moderate precision, which explains why it is more appropriate for population studies than for definitive diagnosis o...

journal_title：International journal of cardiology

authors： D'Alto M,Bossone E,Opotowsky AR,Ghio S,Rudski LG,Naeije R

更新日期：2018-07-15 00:00:00

abstract：BACKGROUND:Lifestyle factors are important in preventing cardiovascular disease (CVD) development. We aimed to systematically review guidelines on primary prevention of CVD and their recommendations on lifestyle advice or intervention, in order to guide primary prevention programs. METHODS:Publications in MEDLINE, CIN...

journal_title：International journal of cardiology

authors： Khanji MY,van Waardhuizen CN,Bicalho VVS,Ferket BS,Hunink MGM,Petersen SE

更新日期：2018-07-15 00:00:00

abstract：OBJECTIVE:We investigated a full energetic profile of pressure and volume loaded right ventricle (RV) in porcine models by evaluating kinetic energy (KE), stroke power, power output and power loss across pulmonary valves with stenosis (PS) or with regurgitation (PR). METHODS:Fifteen pigs (6 PS and 6 PR, 3 unoperated c...

journal_title：International journal of cardiology

authors： Fernandes JF,Hammel JM,Zhou J,Xiao Y,Chen M,Alves R,Lof J,Grieve SM,Schuster A,Kuehne T,Kutty S

更新日期：2018-07-15 00:00:00

abstract：OBJECTIVES:Chronic kidney disease (CKD) is a risk factor for peripheral artery disease (PAD), but the impact of CKD in PAD patients who received endovascular treatment (EVT) is not well studied. Aim of this study is to clarify the impact of CKD in patients with PAD in real EVT era. METHODS:Using the Korean Vascular In...

journal_title：International journal of cardiology

authors： Kim HO,Kim JM,Woo JS,Choi D,Ko YG,Ahn CM,Lee SW,Lee JH,Choi SH,Yu CW,Min PK,Yoon CH,Chae IH,Lee SR,Koh YS,Kim W,other The Korean Vascular Intervention Society (K-VIS) Endovascular therapy in Lower Limb Artery diseases reg

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:The nocebo effect, where patients with expectations of adverse effects are more likely to experience them, may contribute to the high rate of statin intolerance found in observational studies. Information that patients read on the internet may be a precipitant of this effect. The objective of the study was t...

journal_title：International journal of cardiology

authors： Khan S,Holbrook A,Shah BR

更新日期：2018-07-01 00:00:00

abstract：AIM:A fluid challenge with rapid saline infusion during right heart catheterization has been shown to be useful for the differential diagnosis between pre- and post-capillary pulmonary hypertension. The aim of this study was to evaluate the prognostic relevance of fluid challenge-induced changes in pulmonary hemodynami...

journal_title：International journal of cardiology

authors： D'Alto M,Motoji Y,Romeo E,Argiento P,Di Marco GM,Mattera Iacono A,D'Andrea A,Rea G,Golino P,Naeije R

更新日期：2018-06-15 00:00:00

abstract：BACKGROUND:Use of oral anticoagulant (OAC) therapy in atrial fibrillation (AF) is associated with an inherited risk of bleeding. Benefits and risks of OAC restarting after a major bleeding are still uncertain. We aimed to assess effectiveness and safety of restarting OAC in AF patients after a major bleeding event. ME...

journal_title：International journal of cardiology

authors： Proietti M,Romiti GF,Romanazzi I,Farcomeni A,Staerk L,Nielsen PB,Lip GYH

更新日期：2018-06-15 00:00:00

abstract：BACKGROUND:Cardiovascular comorbidities are common in chronic obstructive pulmonary disease (COPD). We examined the association between airflow limitation, hyperinflation and the left ventricle (LV). METHODS:Patients from the COPD cohort COSYCONET underwent evaluations including forced expiratory volume in 1 s (FEV1),...

journal_title：International journal of cardiology

authors： Alter P,Jörres RA,Watz H,Welte T,Gläser S,Schulz H,Bals R,Karch A,Wouters EFM,Vestbo J,Young D,Vogelmeier CF

更新日期：2018-06-15 00:00:00

abstract：BACKGROUND:It is unclear whether ischemic stroke patients with known atrial fibrillation (KAF) had different outcomes than those with atrial fibrillation diagnosed after stroke (AFDAS). We aimed to explore the characteristics and outcomes in ischemic stroke patients with KAF or AFDAS. METHODS:Consecutive patients hosp...

journal_title：International journal of cardiology

authors： Hsieh CY,Lee CH,Wu DP,Sung SF

更新日期：2018-06-15 00:00:00

abstract：OBJECTIVE:Vitamin K antagonists (VKA) are associated with increased vascular calcification which may lead to an elevated cardiovascular risk. If the direct anticoagulants (DOACs) have similar negative vascular effects is unknown. We evaluated the influence of different anticoagulation strategies on coronary artery dise...

journal_title：International journal of cardiology

authors： Plank F,Beyer C,Friedrich G,Stühlinger M,Hintringer F,Dichtl W,Wildauer M,Feuchtner G

更新日期：2018-06-01 00:00:00

abstract：AIMS:The association between aortic valve sclerosis (AVSc) and cardiovascular (CV) events is not consistent among different studies. We have performed a meta-analysis evaluating the association between AVSc and fatal and/or non-fatal CV and cerebrovascular events. METHODS AND RESULTS:A systematic search was performed ...

journal_title：International journal of cardiology

authors： Di Minno MND,Di Minno A,Ambrosino P,Songia P,Pepi M,Tremoli E,Poggio P

更新日期：2018-06-01 00:00:00

abstract：INTRODUCTION:We aimed to study the prevalence and types of sleep apnea (SA) as well as their clinical characteristics in atrial fibrillation (AF) ablation candidates in Japan. METHODS:Before catheter ablation, 197 consecutive AF patients (age: 60 ± 9 years, body mass index; 25.0 ± 3.0) were evaluated with portable pol...

journal_title：International journal of cardiology

authors： Kohno T,Kimura T,Fukunaga K,Yamasawa W,Fujisawa T,Fukuoka R,Nakajima K,Kashimura S,Kunitomi A,Katsumata Y,Nishiyama T,Nishiyama N,Aizawa Y,Fukuda K,Takatsuki S

更新日期：2018-06-01 00:00:00

abstract：INTRODUCTION:Exercise ECG (Ex-ECG) is advocated by guidelines for patients with low - intermediate probability of coronary artery disease (CAD). However, there are no randomized studies comparing Ex-ECG with exercise stress echocardiography (ESE) evaluating long term cost-effectiveness of each management strategy. MET...

journal_title：International journal of cardiology

authors： Gurunathan S,Zacharias K,Akhtar M,Ahmed A,Mehta V,Karogiannis N,Vamvakidou A,Khattar R,Senior R

更新日期：2018-05-15 00:00:00

abstract：BACKGROUND:The definitive role of phosphatidylserine (PS) in the prothrombotic state of non-valvular atrial fibrillation (NVAF) remains unclear. Our objectives were to study the PS exposure on blood cells and microparticles (MPs) in NVAF, and evaluate their procoagulant activity (PCA). METHODS:NVAF patients without (n...

journal_title：International journal of cardiology

authors： Wang L,Bi Y,Yu M,Li T,Tong D,Yang X,Zhang C,Guo L,Wang C,Kou Y,Dong Z,Novakovic VA,Tian Y,Kou J,Shammas MA,Shi J

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:In general, women have lower risk for cardiovascular disease. We tested whether this sex-specific protection persists also in the presence of hypertensive left ventricular hypertrophy (LVH). METHODS:12,329 women and men with hypertension and free from prevalent cardiovascular disease enrolled in the prospec...

journal_title：International journal of cardiology

authors： Gerdts E,Izzo R,Mancusi C,Losi MA,Manzi MV,Canciello G,De Luca N,Trimarco B,de Simone G

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:After introduction of up-titration strategy, there are limited data on comparison between the effects of angiotensin converting enzyme inhibitors (ACEI) and angiotensin receptor blocker (ARB) in patients with heart failure with reduced ejection fraction (HFrEF). The study sought to investigate the associatio...

journal_title：International journal of cardiology

authors： Choi KH,Lee GY,Choi JO,Jeon ES,Lee HY,Cho HJ,Lee SE,Kim MS,Kim JJ,Hwang KK,Chae SC,Baek SH,Kang SM,Choi DJ,Yoo BS,Kim KH,Park HY,Cho MC,Oh BH

更新日期：2018-04-15 00:00:00

abstract：BACKGROUND:Current guidelines on oral anticoagulation (OAC) in adults with congenital heart disease (ACHD) and atrial arrhythmias (AA) consist of heterogeneous and divergent recommendations with limited level of evidence, possibly leading to diverse OAC management and different outcomes. Therefore, we aimed to evaluate...

journal_title：International journal of cardiology

authors： Yang H,Heidendael JF,de Groot JR,Konings TC,Veen G,van Dijk APJ,Meijboom FJ,Sieswerda GT,Post MC,Winter MM,Mulder BJM,Bouma BJ

更新日期：2018-04-15 00:00:00

abstract：AIMS:The activated AMP activated protein kinase (AMPK) serves as a transient protective cardiovascular kinase via preserving adenosine triphosphate (ATP) production under ischemic conditions. However, recent studies reveal that inhibition of AMPK in stroke is neuroprotection. Pigment epithelium derived factor (PEDF) is...

journal_title：International journal of cardiology

authors： Qiu F,Zhang H,Yuan Y,Liu Z,Huang B,Miao H,Liu X,Zhao Q,Zhang H,Dong H,Zhang Z

更新日期：2018-04-15 00:00:00

abstract：BACKGROUND:To investigate the impact of concomitant asymptomatic peripheral artery disease (PAD) and pre-existing coronary artery disease (CAD) on cardiovascular events (CVEs) in atrial fibrillation (AF) patients. METHODS:Prospective multicenter study including 1138 anticoagulated AF patients. PAD was diagnosed by can...

journal_title：International journal of cardiology

authors： Pastori D,Pignatelli P,Sciacqua A,Perticone M,Violi F,Lip GYH

更新日期：2018-03-15 00:00:00

abstract：INTRODUCTION:A number of challenges can affect long-term performance of endocardial implanted systems in pediatric patients. Select Secure™ lead offers potential advantages for this population. This analysis aims to evaluate long-term performance of this lead in children, with and without congenital heart disease. MET...

journal_title：International journal of cardiology

authors： De Filippo P,Giofrè F,Leidi C,Senni M,Ferrari P

更新日期：2018-03-15 00:00:00

abstract：AIM:To determine the prevalence of unidentified bicuspid aortic valve (BAV) or aortic dilatation (>40mm) in first degree relatives (FDR) of patients with isolated BAV in a general hospital. METHODS AND RESULTS:Patients with isolated BAV received information advising cardiac screening of their FDR. Referred and screene...

journal_title：International journal of cardiology

authors： Cozijnsen L,van der Zaag-Loonen HJ,Braam RL,Bakker-de Boo M,Post JG,Bouma BJ,Mulder BJM

更新日期：2018-03-15 00:00:00

abstract：BACKGROUND:Progressive thinning and dilation of the LV due to ischemic heart failure (IHF) increases wall stress and myocardial oxygen consumption. Injectable biopolymers implanted in the myocardial wall have been used to increase wall thickness to reduce chamber volume, decrease wall stress, and improve cardiac functi...

journal_title：International journal of cardiology

authors： Choy JS,Leng S,Acevedo-Bolton G,Shaul S,Fu L,Guo X,Zhong L,Guccione JM,Kassab GS

更新日期：2018-03-15 00:00:00

abstract：BACKGROUND:The role of right atrial (RA) dysfunction in patients with pulmonary hypertension (PH), as evaluated by two-dimensional speckle-tracking echocardiography (2D-STE) remains to be determined. METHODS:Sixty consecutive PH patients and 30 healthy volunteers were included. RA function was evaluated by 2D-STE, and...

journal_title：International journal of cardiology

authors： Meng X,Li Y,Li H,Wang Y,Zhu W,Lu X

更新日期：2018-03-15 00:00:00

abstract：BACKGROUND:Emerging evidence indicates gut microbes and their products could activate the autonomic nervous system (ANS), which plays important roles in the initiation and maintenance of atrial fibrillation (AF). Trimethylamine N-oxide (TMAO), a metabolite derived from gut microbes, is associated with cardiovascular di...

journal_title：International journal of cardiology

authors： Yu L,Meng G,Huang B,Zhou X,Stavrakis S,Wang M,Li X,Zhou L,Wang Y,Wang M,Wang Z,Deng J,Po SS,Jiang H

更新日期：2018-03-15 00:00:00